The premises were first mentioned in a lease from Charles William Bury to John Shaw in 1790. It became a brewery in 1805 when Richard Deverell acquired the property. The ownership changed again, i.e. to George Wilkinson, a baker, in the 1850s.
Michael McGinn (1879-1973) bought the premises in 1920 from the widow Brophy under whose ownership a pub was run by the Keeney family. McGinn was from Mountmellick and managed a D. E. Williams grocery shop there before he bought the pub in Tullamore. He continued the pub trade and also operated a bakery and a grocery on the premises. The licence was transferred in 1967 to his son Philip McGinn who renovated the pub in 1978 and changed the grocery part to an off-licence in 1980.

The distillery was founded in 1757 by Matthew MacManus, and went through several owners until by 1843 it had been taken over by John Locke who transformed its fortunes. In 1893 it became a limited company. The 20th century saw a decline in profitability and by 1958, the distillery ceased production. In 1982, it re-opened as a whiskey distillery museum following restoration by the Kilbeggan Preservation and Development Association. In 2007 distilling recommenced at Kilbeggan and it is known now as Kilbeggan Distillery.